- Formulated for the GLP-1 journey
- No melatonin, no proprietary blends
- Cancel subscriptions anytime
- Made in a third-party certified cGMP facility
Protocol nr
Nighttime support for sleep, recovery and skin, made for the GLP-1 journey.*
As little as 78¢ a day with Subscribe
- Sleep: fall asleep and stay asleep, with no melatonin*
- Recovery: supports a healthy stress response and overnight recovery*
- Skin: hyaluronic acid and fruit polyphenols, from within*
- Free shipping on orders over $100
- Formulated for GLP-1 patients
The Method
Protocol nr supports restful sleep and your body's overnight recovery while you're on a GLP-1.* Taken before bed, it brings together calming amino acids, gentle magnesium, plant flavonoids and hyaluronic acid for skin hydration from within. No melatonin.*
Protocol nr is not a weight loss product.
Key Ingredients
Glycine, L-theanine and magnesium bisglycinate support calm and restful sleep.*
Apigenin and honokiol, plant compounds that support relaxation.*
Phosphatidylserine, taurine and active vitamin B6 support your body's overnight recovery and a healthy stress response.*
Hyaluronic acid and fruit polyphenols support skin hydration and antioxidant defense from within.*
Supplement Facts
Serving size: 4 vegetarian capsules · 30 servings
Vitamin B6 (as P5P) 15 mg (882% DV) · Magnesium (as Albion® magnesium bisglycinate chelate buffered, TRAACS®) 300 mg (71% DV) · L-Glycine 870 mg · L-Theanine 250 mg · L-Taurine 250 mg · Raiā-AFC™ fruit polyphenols (New Zealand blackcurrants, boysenberries, grapes and kiwifruits) 155 mg · Hyaluronic acid (as sodium hyaluronate) 150 mg · Phosphatidylserine (from sunflower) 98 mg · Apigenin 100 mg · Honokiol 15 mg
Other ingredients: vegetarian capsule (hypromellose), citric acid, maltodextrin, silica.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
How to Use
Adults begin with 2 capsules approximately 30 to 60 minutes before bedtime, or as directed by a qualified healthcare practitioner, to assess individual tolerance and response. If additional sleep support is desired and the initial serving is well tolerated, gradually increase to 3 capsules, then 4 capsules as needed. Individual responses may vary. Do not exceed 4 capsules daily.
Talk to your healthcare provider before starting any new supplement, especially if you take prescription medication.
What happens when you sleep on nr.
On a GLP-1 your body and skin change fast. Night is when they catch up.
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Sleep
Unwind before bed
Helps a busy mind switch off.*
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Sleep
Sleep through the night
Made to help you stay asleep, not just drift off.*
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Recovery
Wake up restored
Supports your body's overnight recovery.*
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Recovery
A calmer stress response
Cortisol should fall at night. Supports a healthy stress response.*
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Skin
Skin that feels hydrated
150 mg of hyaluronic acid, for hydration from within.*
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Skin
Skin defended from within
Fruit polyphenols help protect your cells from oxidative stress.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
What's in every capsule, and why.
Ten ingredients, three jobs. No melatonin, no proprietary blends.
Tap a capsule to see what's inside 3 jobs · 10 ingredients
Sleep and calm
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Glycine
An amino acid that supports restful sleep.*
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L-theanine
An amino acid found in green tea
Supports calm and relaxation.*
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Magnesium
Gentle bisglycinate form
Supports relaxation and normal muscle function.*
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Apigenin
The flavonoid found in chamomile
A plant flavonoid that supports relaxation.*
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Honokiol
From magnolia bark
Supports calm.*
Overnight recovery
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Phosphatidylserine
From sunflower
Supports a healthy stress response.*
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Taurine
An amino acid that supports normal cellular function.*
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Vitamin B6
Active P5P form, supports normal nervous system function.*
Skin and defense
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Hyaluronic acid
Studied in placebo-controlled human trials for skin moisture.*
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Fruit polyphenols
Raiā-AFC™ New Zealand fruit complex
62% polyphenols, for antioxidant defense.*
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L-theanine
Self-reported sleep quality scores improved, versus placebo.Randomized, double-blind, placebo-controlled crossover · 30 healthy adults · 4 weeks · 200 mg a day
Hidese et al., Nutrients, 2019 · Read the study
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Magnesium bisglycinate
A modest improvement in self-reported sleep scores, versus placebo.Randomized, double-blind, placebo-controlled · 155 healthy adults reporting poor sleep · 4 weeks · 250 mg a day
Schuster et al., Nature and Science of Sleep, 2025 · Read the study
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Hyaluronic acid
Measured skin moisture, elasticity and wrinkles improved, versus placebo.Randomized, double-blind, placebo-controlled · 40 healthy adults · 12 weeks · 120 mg a day
Hsu et al., Nutrients, 2021 · Read the study
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Hyaluronic acid
Skin hydration and elasticity improved and wrinkle depth decreased, versus placebo.Randomized, double-blind, placebo-controlled · 150 healthy adults · 12 weeks · 60 or 120 mg a day
Dolečková et al., Scientific Reports, 2025 · Read the study
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Hyaluronic acid
Skin moisture increased more than with placebo.Randomized, double-blind, placebo-controlled · 61 adults with dry skin · 6 weeks · 120 mg a day
Kawada et al., Journal of Clinical Biochemistry and Nutrition, 2015 · Read the study
More than a sleep aid.
Protocol nr
Compares what is in each, not how well it works.
Inside and out
One routine for your skin.
nr for your nights, io for your days, and the Moisturizer on your skin.
Add either one, ship free
FAQ
When do I take it?
When do I take it?
Start with 2 capsules, 30 to 60 minutes before bedtime. If well tolerated, gradually increase to 3, then 4 as needed. Do not exceed 4 capsules daily.
Does it contain melatonin?
Does it contain melatonin?
No. Protocol nr has no melatonin.
What does stress have to do with sleep?
What does stress have to do with sleep?
Cortisol, your stress hormone, is meant to fall in the evening so your body can switch off. Phosphatidylserine, L-theanine and magnesium support relaxation and a healthy stress response.*
Can I take it with my GLP-1 medication?
Can I take it with my GLP-1 medication?
Protocol nr is a dietary supplement, not a medication. Talk to your healthcare provider before starting any new supplement, especially if you take prescription medication.
Can I take it with Protocol io?
Can I take it with Protocol io?
Yes. Protocol io is built for the day and Protocol nr for the night, so many people take both.
Is it a weight loss product?
Is it a weight loss product?
No. Protocol nr supports sleep, overnight recovery and skin hydration while you're on a GLP-1.* It does not cause weight loss.
What's in it?
What's in it?
Glycine, L-theanine, magnesium bisglycinate, apigenin, honokiol, phosphatidylserine, taurine, active vitamin B6, hyaluronic acid and fruit polyphenols. The full Supplement Facts panel is in the details at the top of the page.
Can I cancel my subscription?
Can I cancel my subscription?
Yes. You can cancel anytime.
Can I take it if I'm not on a GLP-1?
Can I take it if I'm not on a GLP-1?
Yes. It's formulated with the GLP-1 journey in mind, and anyone looking for nighttime support can use it. Talk to your healthcare provider first.
