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A serum bottle surrounded by floating spheres on an orange background.Close-up of a person's face with naturally glowing skin.
Bottle and box of Longevity Hybrid Defense Serum on a wooden tray with a towel.

5 Star Reviews

Longevity Hybrid Defense Serum

Our premium serum strengthens your skin’s resilience, restoring a youthful glow. It combats environmental stressors, reduces aging signs, and improves texture and tone for a smoother, more even complexion. 

Science-Driven Formulas
Natural Ingredients
Suitable for any skin type
All Ingredients

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$51.20

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$64.00
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FAQs

Q: Can I use this serum with other products?

A: Yes, it complements other skincare routines. Apply after cleansing and toning, before moisturizing.

Q: Is it suitable for sensitive skin?

A: Yes, our formula is gentle yet effective for all skin types, including sensitive skin.

Hybrid Defense is our science-driven approach, combining potent antioxidants, acai stem cells, and peptides to defend against environmental stressors, rejuvenate skin, and boost radiance—all in one comprehensive formula.

Transformative care, powered by science—where radiant skin meets lasting confidence

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What's Inside

How To Use

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These four forms of vitamin C derivatives—L-ascorbic acid, 3-glyceryl ascorbate, tetrahexyldecyl ascorbate, and magnesium ascorbyl phosphate—work synergistically to provide comprehensive skincare benefits. L-ascorbic acid delivers immediate antioxidant protection and stimulates collagen production, while 3-glyceryl ascorbate hydrates and supports mild antioxidant activity, making it suitable for sensitive skin.


Tetrahexyldecyl ascorbate penetrates deeply into the skin, enhancing collagen synthesis and reducing oxidative stress, and magnesium ascorbyl phosphate offers stable, gentle brightening and anti-aging effects. Together, these derivatives provide a multi-layered approach, ensuring both immediate and sustained skin benefits with enhanced stability, hydration, and anti-aging support, making them practical for a wide range of skin types.

Time to Work
24-Hour Defense
After Effects
Immediate Glow
The Science
Cellular Repair
Experience More
Lasting Resilience
Get Results with
Molecular Damage Repair
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Four Vitamin C’s
Resveratrol
Fulvic Acid with 80 Trace Minerals
Acai Stem Cells
Triple Peptide Complex
Hyaluronic Acid
Pricing
Logo with three overlapping circles and the word 'Meticulous'.
$64/mo
Skin Ceuticals
CE Ferulic
~$182/mo
Drunk Elephant
C-Firma™ Fresh Day Serum
~$79/mo
Bottle of Longevity Hybrid Defense Serum with dropper, 30ml.

Longevity Hybrid Defense Serum

All Skin Types
Anti-Aging
$64.00
Two people side by side, both smiling gently at the camera.

Precision. Potency. Proven Results.

Science-Driven Formulas 

Pure, Potent Ingredients

Enhanced Bioavailability

Skincare serum box with benefits listed: antioxidant protection, brightening, anti-aging, hydration, and collagen boost.
Your Daily Defense Against Dullness
No more dull, tired skin.
No more uneven skin tone.
No more rough texture.
No more heavy formulas.
5.0
Rated 5.0 out of 5 stars
Based on 9 reviews
Total 5 star reviews: 9 Total 4 star reviews: 0 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 0
100%would recommend this product
9 reviews
  • CP Profile picture for Clarice P.
    Clarice P.
    I recommend this product
    Rated 5 out of 5 stars
    15 seconds ago
    Really Liked it!!

    I really like the texture of the serum on my skin. It blends very well and has a soft touch, without leaving the skin thick or oily.

    It is already part of my daily skin care routine, especially because it works very well applied before sunscreen and makeup, leaving a touch of glow on the skin.

  • KJ Profile picture for Katie J.
    Katie J.
    I recommend this product
    Rated 5 out of 5 stars
    1 minute ago
    Love this serum!

    Love this serum! It feels similar to a favorite vitamin C serum I’ve bought from the dermatologist.

    It works great and doesn’t bother my super-sensitive skin like a few others I’ve tried. Absorbs quickly and doesn’t affect my makeup application.

  • LO Profile picture for Lindsey O.
    Lindsey O.
    I recommend this product
    Rated 5 out of 5 stars
    2 minutes ago
    Loved itt!!

    Meticulous Longevity Hybrid Defense Serum is the best skincare product, and I have tried them all! I previously used SkinCeuticals CE Ferulic, but as I got older and my skin got more dry, I switched to SkinCeuticals Phloretin CF, which I’ve been using and loving for years.

    I was hesitant to try something new, but I'm so glad I did! Meticulous serum gives me all of the benefits I had before, but now my skin feels softer and more hydrated, and I’ve noticed less fine lines/wrinkles. It’s so much less expensive than SkinCeuticals, and I no longer need an additional moisturizer.

    I also love that the brand Meticulous is science-based and ethical, and I can trust their ingredients are always of high quality and beneficial. I hope they come out with more products soon!

  • GM Profile picture for Grayson M.
    Grayson M.
    I recommend this product
    Rated 5 out of 5 stars
    5 minutes ago
    Couldn’t recommend it more!

    The Longevity Hybrid Defense Serum has completely changed the skincare game for me. Having struggled with acne most of my life, I’ve tried countless products to try to manage it. Nothing has worked as well or as fast as this serum.

    My skin has become significantly less textured, and any acne that appears now is minimal and only sticks around for a day or two. I’m obsessed with this product and stunned by the results. I couldn’t recommend it more!

  • DT Profile picture for Dr. Thayla Ferrari, D.
    Dr. Thayla Ferrari, D.
    I recommend this product
    Rated 5 out of 5 stars
    9 minutes ago
    Game Changer

    An amazing cosmetic can give you beautiful skin while highlighting your natural beauty.

    These days, Dermatology has been all about ‘Beautification’—focusing on enhancing what makes each person uniquely beautiful.

    You don’t need a super complicated skincare routine that takes forever or leaves you with many products collecting dust in your cabinet.

    And you definitely don’t need invasive procedures that change your features, build up over time, and, according to some studies, might even be linked to autoimmune issues.

    For me, the real goal is aging gracefully and healthily, keeping oxidative stress in check. This natural part of aging speeds up with things like hormonal or nutritional imbalances, chronic stress, poor sleep, or habits like smoking and regular alcohol consumption.

    That’s why this product is such a game-changer—with its powerful blend of antioxidants, stem cells, and peptides!

    It absorbs beautifully, delivers real results, and is so easy to use. You’ve got to try it!

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Science Meets Nature
Our years of discovering globally best of class, whole food, plant-based ingredients that truly provide efficacious results at UB Super led us down this path to create Meticulous Skincare.
Meticulous Skincare combines years of expertise in plant-based innovation with future groundbreaking clinical studies in partnership with Integrated Molecular Therapeutics. Our research, including new initiatives in Brazil, is redefining skincare with supplementation with precision and science at its core.

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