- Formulated for the GLP-1 journey
- No stimulants, no proprietary blends
- Cancel subscriptions anytime
- Made in a third-party certified cGMP facility
Protocol io
Daily support for energy, skin and antioxidant defense, made for the GLP-1 journey.*
$1.83 a day with Subscribe
- Energy: supports healthy NAD+ and cellular energy, without stimulants*
- Skin: astaxanthin, glutathione and vitamin C, from within*
- Defense: a network of antioxidants for when your plate gets smaller*
- Free shipping on orders over $100
- Formulated for GLP-1 patients
The Method
Protocol io helps you keep getting healthier on a GLP-1, from within.* Three capsules a day for NAD+, cellular energy and antioxidant defense, with ingredients studied for skin. The serum and moisturizer work on the surface. Protocol io works from within.*
It is not a weight loss product, and it is not intended to replace food or a balanced diet.
Key Ingredients
Nicotinamide riboside, PQQ and CoQ10 support healthy NAD+ levels and cellular energy, without stimulants.*
Astaxanthin, liposomal glutathione and CoQ10, each studied for skin.*
Plant-derived vitamin C supports collagen formation and skin elasticity from within.*
L-ergothioneine, plant vitamins A and E, PEA and fulvic acid trace minerals round out multi pathway antioxidant defense from within.*
Supplement Facts
Serving size: 3 vegetarian capsules · Servings per container: 30
Vitamin A (as natural beta-carotene from annatto seed) 250 mcg RAE (28% DV) · Vitamin C (from amla) 30 mg (33% DV) · Vitamin E (from annatto seed) 15 mg (100% DV) · Palmitoylethanolamide (PEA) 600 mg · Nicotinamide riboside chloride 250 mg · L-Glutathione (from 400 mg liposomal glutathione) 200 mg · Fulvic acid ionic mineral complex (Ioniplex®) 150 mg · CoQ10 (ubiquinone) 100 mg · PQQ 20 mg · L-Ergothioneine 15 mg · Natural astaxanthin 12 mg. Daily Value not established for ingredients without a % DV.
Other ingredients: Vegetarian capsule (hypromellose).
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
How to Use
Take with water in the morning, preferably with food, following the serving directions on the label.
Talk to your healthcare provider before starting any new supplement, especially if you take prescription medication.
What happens when you take io every day.
On a GLP-1 you eat less. Your cells still need the same.
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Energy
Steady energy, no stimulants
Supports NAD+, which your cells use to turn food into energy.*
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Energy
Fuel for your cells
CoQ10 and PQQ support the mitochondria that power your cells.*
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Skin
Skin supported from within
Astaxanthin, studied in human trials for skin moisture.*
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Skin
Collagen support
Vitamin C from amla supports normal collagen formation.*
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Defense
Everyday antioxidant defense
A network of antioxidants that help protect your cells.*
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Defense
Vitamins from plants
Vitamins A, C and E from amla fruit and annatto seed.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Where our vitamins come from
Many vitamins are made in a lab from petrochemicals. Ours come from plants.
The vitamins A, C and E in Protocol io come from amla fruit and annatto seed.
What's in every capsule, and why.
Eleven ingredients, three jobs. No proprietary blends, no stimulants.
Tap a capsule to see what's inside 3 jobs · 11 ingredients
Cellular energy
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Nicotinamide riboside
A building block your body uses to make NAD+, which cells need to turn food into energy.*
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CoQ10
Works inside your mitochondria to help produce cellular energy.*
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PQQ
Supports healthy mitochondrial function.*
Skin from within
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Astaxanthin
From red microalgae
An antioxidant studied for skin moisture and fine lines.*
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Vitamin C
From amla berry
Supports normal collagen formation.*
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Vitamin A
From annatto seed
Supports healthy skin.*
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Liposomal glutathione
Your body's own key antioxidant, delivered in liposomes.*
Everyday defense
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PEA
The largest dose in the capsule
Supports a healthy inflammatory response and everyday comfort.*
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Ergothioneine
An antioxidant found in mushrooms
An antioxidant your cells take up and hold onto.*
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Vitamin E
From annatto seed
Helps protect cells from oxidative stress.*
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Fulvic mineral complex
A complex of trace minerals.*
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Nicotinamide riboside
Raised blood NAD+ levels within two weeks, versus placebo.Randomized, double-blind, placebo-controlled · overweight but otherwise healthy adults · 8 weeks · 100 to 1,000 mg a day
Conze et al., Scientific Reports, 2019 · Read the study
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PQQ
Increased a marker of new mitochondria, versus placebo.Randomized, placebo-controlled · 23 untrained men · 6 weeks · 20 mg a day
Hwang et al., Journal of the American College of Nutrition, 2020 · Read the study
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CoQ10
Fewer wrinkles and fine lines, and smoother skin, versus placebo.Randomized, double-blind, placebo-controlled · 33 healthy adults · 12 weeks · 50 or 150 mg a day
Žmitek et al., BioFactors, 2017 · Read the study
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Astaxanthin
Skin moisture and fine lines held steady, while the placebo group's declined.Placebo-controlled · 65 healthy women · 16 weeks · 12 mg a day
Tominaga et al., Journal of Clinical Biochemistry and Nutrition, 2017 · Read the study
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Astaxanthin
Crow's-feet wrinkles and skin elasticity improved.Randomized, double-blind, placebo-controlled · 36 healthy men · 6 weeks · 6 mg a day
Tominaga et al., Acta Biochimica Polonica, 2012 · Read the study
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Astaxanthin
Skin lost less moisture after UV exposure, versus placebo.Randomized, double-blind, placebo-controlled · 23 healthy adults · 10 weeks · 4 mg a day
Ito et al., Nutrients, 2018 · Read the study
More than a multivitamin.
Protocol io
Compares what is in each, not how well it works.
Inside and out
One routine for your skin.
io from within. The Serum and Moisturizer on your skin.
Add either one, ship free
FAQ
When do I take it?
When do I take it?
In the morning with water, preferably with food, following the serving directions on the label.
Can I take it with my GLP-1 medication?
Can I take it with my GLP-1 medication?
Protocol io isn't tied to any medication. Talk to your provider before starting any new supplement, especially if you take prescription medication.
Will it make me jittery?
Will it make me jittery?
No. There is no caffeine or stimulant in Protocol io. The energy support is at the cellular level, not the kind you feel in your head.*
Is it a weight loss product?
Is it a weight loss product?
No. It supports your body while it changes. It is not intended to replace food or a balanced diet.
Do I need the serum and moisturizer too?
Do I need the serum and moisturizer too?
No. Each product works on its own. Protocol io works from within, and the serum and moisturizer work on the surface, so they pair well if you want both.
What's in it?
What's in it?
Every ingredient and every amount is on the Supplement Facts panel. We don't use proprietary blends.
Can I cancel my subscription?
Can I cancel my subscription?
Yes, anytime. Manage or cancel from your account, or email support@meticulousskincare.com.
Can I take it if I'm not on a GLP-1?
Can I take it if I'm not on a GLP-1?
Yes. It's formulated for the rapid change of a GLP-1 journey, but nothing in it depends on being on one.
